Contraindications for Effexor

Effexor is a popular antidepressant agent manufactured by Wyeth. It is the first medicine from the drug class of serotonin-norepinephrine reuptake inhibitors or SNRIs.

The main component in Effexor is Venlaflaxine approved by the FDA for the treatment of major depressive disorder. Besides, the medicine is added to the list of optional treatments for people who suffer from generalized anxiety disorder, panic disorders, social phobias and other mental issues.

Effexor is prescribed for various other purposes not mentioned in the uses label. Doctors prescribe it off-label for migraine pains, to relief hot flashes in post menopause and menopause women, to treat diabetic neuropathy symptoms and others.

Effexor effectively manages the symptoms of major depressive disorder by blocking the chemicals in the brain and regulating the levels of serotonin and norepinephrine. It helps to prevent and treat depression and generalized anxiety, targets panic attacks and other symptoms. The medicine shows few side effects and can be adjusted safely for most the patients. Still some of the patients must not use this medicine. When taken by pregnant women,

Effexor may increase the risk of birth defects. This serious complication is linked to the use of certain SNRI and SSRI antidepressants. Women, who are pregnant, must not use Effexor or other similar antidepressants. For pregnant women there is a special warning from the manufacturer of this medicine. The safety of this medicine use during pregnancy was not established during clinical trials.

The studies proved that the medicine can harm an unborn baby and cause serious birth defects and other complications. Thus the medicine is given the warning status of pregnancy category C. Women who are pregnant and suffer from depressive states should discuss with their doctors the possibilities of other methods of treatment.

The use of Effexor by pregnant women also increases the risk of miscarriage significantly. The manufacturer warns the consumers about possible serious risks associated with this drug.

Effexor just like any other antidepressant with potent actions, can be contraindicated for people younger than14 years of age. Such patients should be closely monitored by doctors during the treatment. Caregivers, parents and medical experts should watch for the behavior changes, mood changes and other warning signs of suicidal tendencies.

Suicidal attempts can increase with the use of Effexor. The prescription of this medicine for people younger than 24 years of age should be justified and proven by a doctor.

Among contraindications for Effexor there is hypersensitivity reaction to the components in the medicine. These may include any severe or moderate allergic reactions of a patient and anaphylactic shock. This medicine is contraindicated for patients who have been treated with MAOIs. MAOIs should not be combined with Effexor because of the risk of serotonin syndrome development. Effexor should not be used in patients who have previously had serious side effects caused by this medicine.

Indications and Usage for Effexor

Effexor tablets are indicated for the treatment of major depressive disorder (MDD).depression
The 6 week clinical study was held to assess the efficacy of Effexor in the treatment of MDD. Patients with MDD and melancholia who used Effexor benefited from the treatment significantly compared with patients who were administered placebo.
Patients with episode of depression usually demonstrate the following symptoms which last for more than 2 weeks:
•    Insomnia;
•    Phychomotor agitation or retardation;
•    Appetite changes;
•    No interest in everyday activities;
•    Increased fatigue;
•    Mood changes, persistent sad mood or feelings.
Besides patients with major depression can have suicide thoughts or attempts.
Effexor extended-release capsules hold its antidepressant effect for up to 26 weeks after 8 weeks of acute treatment. The treatment of acute periods of depression should be initiated as soon as possible. Drug choice is usually made by a doctor. If you decide to use this medicine consult your doctor first.

Effexor’s results

iCAHO63BXThis drug saved my life two years ago. I feeling as if suicide would be the only way out, I was extremely anxious and stressed. Effexor turned all my life around. My social circle has increased tenfold,I have gotten two promotions at my job,  and I always feel on top of my game. The withdrawals do suck at first if you forget a dose. I’m glad I did, but I was scared to try Effexor at first.


This drug  is an antidepressant in a group of medicine called SSNRIs* . Effexor is used to treat major anxiety, depressive disorder, panic disorder .

Venlafaxine  may cause depression, because affects chemicals in the brain.

 *selective serotonin and norepinephrine reuptake inhibitors

Important information


If you miss a dose

Take the missed dose of Effexor at once as posible. You shouldn’t take extra drug to make up the missed dose of Effexor.

You should avoid while taking this drug  

Don’t drink alcohol,if you take Effexor, because alcohol can increase side effects of this drug.   Very important to know that this drug  may impair your reactions and thinking . Be careful if you drive a car, after take Effexor


Call at once your doctor!!!    Symptoms of overdosemay include fast heart rate,vomiting,  blurred vision,seizure or extreme drowsiness.

Before taking Effexor

You should not take this drug if you have any allergic reaction to desvenlafaxine (Pristiq),venlafaxin, or if you are also using MAOI (a monoamine oxidase inhibitor) such as isocarboxazid (Marplan), rasagiline (Azilect), furazolidone (Furoxone), phenelzine (Nardil) or tranylcypromine (Parnate) or selegiline (Emsam, Eldepryl ).   Do not take this drug together with desvenlafaxine (Pristiq).

And also consult with health care provider if you have the next problems, such as:

• manic depression;

• blood clotting disorder  ;

• liver disease (cirrhosis);

• high blood pressure;

• kidney disease;

• seizures or epilepsy ;

• glaucoma;

• if you are switching to this drug from another antidepressant;

• high cholesterol;


• if you have a low levels of sodium in your blood.

Effexor with other drugs

Call your health care provider if you take or want to take the next drugs:

• ketoconazole (Nizoral);

• warfarin (Coumadin, Jantoven);

• linezolid (Zyvox);

• lithium (LithoBid,Eskalith);

• zolmitriptan (Zomig), frovatriptan (Frova), almotriptan (Axert), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt).

• cimetidine (Tagamet HB,Tagamet );

• tramadol (Ultracet, Ultram);

• risperidone (Risperdal) or haloperidol (Haldol);

• tryptophan (sometimes called L-tryptophan);

• any other antidepressant.


Less serious side effects of Effexor

• blurred vision;

• strange dreams;

•  dizziness,drowsiness, feeling nervous;

• increased sweating;

• changes in weight or appetite ;

• constipation;

• dry mouth;

• impotence,difficulty having an orgasm, decreased sex drive;

• mild nausea.

Side effects

Very important call your doctor at once, if you have new symptoms or allergic reaction. Worsening symptoms may be the next: behavior changes, panic attacks,if you have thoughts about  hurting yourself,anxiety, trouble sleeping, or if you feel irritable,impulsive, hostile,agitated,  hyperactive (physically or mentally ), restless,  aggressive, more depressed.

Side effects:

• convulsions;

• very stiff (rigid) muscles,feeling like you might pass out, confusion,  sweating,uneven or fast   heartbeats, tremors, high fever;

• agitation, fast heart rate,  fever,  nausea,overactive reflexes, vomiting, loss of coordination, chest tightness;

• headache, trouble concentrating, memory problems, weakness, feeling unsteady,confusion,  hallucinations, fainting  or breathing that stops or shallow breathing;

• trouble breathing, cough; or

• easy bruising.